90 capsules A Highly Potent Source of Pancreatic Enzymes
Enteric coated pancreatin tablets were used as digestive aids for a number years before clinical trials showed the tablets to be more effective when the enteric coating was removed and the tablets crushed and administered in capsule form. Pan 10X are supplied as powdered supplements in capsule form.
It is important to note that the functionality of pancreatic enzymes is enhanced by other enzyme systems including salivary amylase, gastric pepsin and intestinal saccharides.
Oral Supplements Increase Enzyme Activity to Nearly Normal in Cases of Pancreatic Insufficiency
In a study on the therapeutic response to oral enzymes in severe pancreatic insufficiency, researchers concluded that “…the administration of these high potency digestive aids, along with meals, does have a very positive clinical influence on reducing malabsorption through improved digestion — when comparing a healthy pancreatic sufficient individual to one with pancreatic insufficiency, the use of pancreatin with meals greatly increases the fat-splitting enzyme activity in the duodenum to nearly normal levels.
Oral enzyme supplements have been effectively used therapeutically in cases of:
Food allergies, Toxic bowel syndrome resulting from overgrowth of gastrointestinal bacteria, Inflammation resulting from trauma, arthritis or allergy.
Malabsorption caused by pancreatic insufficiency resulting from cystic fibrosis, alcoholism or surgical resection of portions of the pancreas or high fat diet.
Pancreatectomy or chronic pancreatitis.
Enhancement of B-12 absorption.
Of the myriad of approximately 30 identified pancreatic enzymes present in Pan 5X and Pan 10X, amylase, lipase and protease are considered to be of greatest physiological importance.
Pancreatic amylase digests starch, dextrin’s and glycogen, converting them to maltose, a disaccharide. Pancreatic lipase hydrolyzes dietary fats, splitting them into glycerol and fatty acids.
Pancreatic protease is made up of a mixture of proteolytic enzymes including trypsin, chymotrypsin, carboxypeptidase and elastase. These enzymes initiate the digestion of large protein molecules and fragments, splitting them into still smaller fragments. Proteolytic enzymes have also been shown to reduce inflammation and speed healing in soft tissue injuries.
Pan 10 X were designed primarily as digestive aids. The combination of enzymes in the Inflamase formula are more effective as an anti-inflammatory.
Effective Therapeutic Use of Enzyme Supplements
Effective enzyme therapy requires the administration of sufficient quantities of replacement enzymes. The in vitro activity can be related directly to in vivo potency.
Our most potent supplement, Pan 10X may be used for inflammation and digestive support in acute or severe cases of pancreatic insufficiency, but should not be used for prolonged periods by persons with a healthy, normally functioning pancreas.
Gastric acidity and possibly low duodenal pH may interfere with effective enzyme replacement in some patients. For these patients, the addition of an antacid may be indicated. The pH barrier is usually not a grave problem because hyperacidity is rare in patients with exocrine pancreatic insufficiency; whereas, hypochlorhydria and achlorhydria are common findings.
High fat diets inhibit pancreatic enzyme utilization, which is one of the main causes of protein malabsorption; therefore, supplements will be more effective if a low fat diet is followed.
Used as a digestive aid, pancreatic enzyme supplements should be taken with meals or at the end of a meal.
Proteolytic enzymes used for inflammation or to reduce swelling and speed healing in soft tissue injuries should be taken between meals, on an empty stomach, for maximum effectiveness.
WARNING: This information is provided for the health professionals only. This publication and the product contained herein have not been approved or evaluated by the Food and Drug Administration. This publication, and the product contained herein are not intended to diagnose, treat, cure or prevent any disease. The product relates to nutritional support only.