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| info@vitasentials.com |
1-800-343-4022 | ||||||||||||||||||||
Niacin Non-Flush
| Each Capsule Supplies: 560 mg Inositol Hexanicotinate Will yield 500mg. Flush free Niacin |
Abstract
Inositol nicotinate is a unique complex containing both inositol and niacin molecules. This compound offers distinct advantages over conventional niacin therapy in the control of circulatory problems and elevated cholesterol levels. Inositol nicotinate is superior to niacin in its ability to lower cholesterol without the degree of flushing common to high dose niacin therapy.
Introduction
Recent studies have clearly indicated that reducing blood cholesterol significantly diminishes the risk of cardiovascular disease,1) Healthcare professionals have been urged to institute vigorous blood cholesterol-management programs which include dietary and lifestyle changes. The average American eats 300 to 500 milligrams of cholesterol per day. The American Heart Association recommends a daily intake of less than 300 milligrams per day. 2
) High cholesterol is not the only cause of heart disease or stroke, but consider these facts:About 50% of adult Americans have cholesterol levels above 200 mg/dL and have an increased risk of developing premature heart disease.
Persons with blood cholesterol over 260 have four times the risk of developing heart disease as those with levels of 190 mg/dL or below.
550,000 Americans die every year from coronary heart disease - more than all forms of cancer combined.
The use of a modified Iow-fat diet and special nutritional supplements can lower total blood triglycerides and cholesterol.
Niacin and Cardiovascular Health
The use of niacin in large doses (3-9 grams per day) is an effective and widely used technique for control of blood lipids. Along with bile acid-binding resins and other drugs, it has been a "first-line" medical approach to blood cholesterol and triglyceride control for years.(3,4) Such large doses of niacin reduce blood cholesterol from 10-30% or more, with sometimes dramatic effects on triglycerides, (5,6) Niacin can also inhibit hepatic cholesterol synthesis at the same time it promotes cholesterol catabolism and excretion, specifically for the LDL cholesterols.3,4) By virtue of these actions, niacin raises the HDL/LDL + VLDL (high, Iow, and very low-density lipoprotein) cholesterol ratio - a very desirable change for reducing the risk of cardiovascular disease.
Niacin, in addition to its role in lipid management, stimulates the release of the vasodilator and platelet anti-aggregant, prostacyclin. This action enhances peripheral circulation and may help prevent thrombosis.
Unfortunately, however, ordinary niacin at these levels always causes intense and unpleasant flushing for 30-60 minutes after it is given - a common cause of compliance problems with this therapy. High dose niacin also may cause Gl disturbances such as dyspepsia and diarrhea, and may in select individuals cause more serious side effects such as liver or gall bladder abnormalities, glucose intolerance, hyper-uricemia (gout), or peptic ulceration. These problems have limited the utilization of this otherwise effective treatment.
Inositol Hexaniacinate: An Alternative to Conventional Niacin Therapy
Niacin esters (molecules linking niacin with other organic materials) offer an alternative to ordinary niacin. Therapy with niacin esters is characterized by reduced side effects and enhanced efficacy at the same or lower doses.
Prominent among these compounds is meso-inositol hexanicotinate (inositol nicotinate), which consists of the B vitamin-like factor, inositol, linked with six niacin molecules, Inositol itself has lipotropic properties and plays a role in controlling increases in fatty acids and total cholesterol. In combination, inositol and niacin appear to profoundly enhance their respective cardiovascular benefits.Inositol nicotinate is absorbed intact and is hydrolyzed slowly, releasing its constituents inositol and niacin.
Experimental work with several niacin esters has revealed that sustained increases in the blood levels of niacin - even if the absolute changes are moderate - have greater effects on blood lipids than extreme increases.Advantages of Inositol Nicotinate Inositol nicotinate offers distinct advantages over conventional mega-niacin therapy:.
1. Inositol nicotinate is more effective than niacin alone in reducing elevated blood cholesterol and triglyceride and can help to elevate the HDI./LDL ratio.
2. This particular ester complex of niacin/mositol eliminates the troublesome flushing and reduces long-term hazards that have restricted the use of Mgh dose niacin therapy.
3. May act as a valuable aid in peripheral vascular disease (intermittent:claudicafion).
4. nositol nicotinate should be used in a comprehensive: program of diet and lifestyle modification.
doses of slow-release niacin derivatives such as inositol nicotinate have an influence on blood lipids that is comparable to ordinary (non-esterified) niacin in much larger doses
Inositol Nicotinate and Cholesterol
In an experimental settng, inositol nicotinate exhibited pronounced hypolipidemic activity in both man and animals. Several studies have shown that inositol hexanicotinate is more effective in reducing hypercholesterolemia than was nicotinic acid alone. Dorner and Fischer found that even very low doses separate of inositol nicotinate (6-800 mg/Day) were sufficient to produce a significant hypocholestcrolemic effect in a group of hypercholrsterolemic human subjects. Inositol nicotinate has also been used successfully, in combination with the hypolipemic drug clofibrate, to control human hyperlipidemias.
By virtue of its slow hydrolysis and steady release of niacin, as well as the lower effective doses, inositol nicotinatc offers the therapeutic benefits of mega-niacin therapy with no flushing, and greatly reduced risk for GI distress, or serious side effects. Despite the absence of side effects reported in the literature, however, in any therapeutic regime including high-dose niacin, the patient should be observed for any signs of liver stress or hyperuricemia.Intermittent Claudication
A remarkable volume of evidence has accumulated documenting the efficacy of inositol nicotinate therapy in intermittent claudicafion and other vasculopathirs. Intermittent claudication is a common symptom of generalized atherosclerotic disease marked by exertional Ieg pain in the calf, thigh and hip muscle, but most frequently in the calf muscles. The pain subsides after a brief rest period allowing the patient to walk again without discomfort for a short period of time. A three month clinical study of 113 patients with vascular insufficiency demonstrated that more patients treated with inositol nicotinate had improved claudication times than those patients treated with a placebo. Claudication time was measured at the point whom the patient recorded the onset of calf pain.