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Vitamin E with Tocotrienols
For Lowering Total Cholesterol

Tocotrienols: Recently Available Form of Vitamin E

Vitamin E is made up of eight molecules.  Tocopherols make up four of those molecules; the alpha, beta, delta and gamma tocopherol.  Tocotrienols are identical to the four tocopherols in the ring structures and methyl groups.  However, they differ in the Vitamin E “side chain”, that is, the four tocotreinol molecules are more unsaturated.

The tocopherols have been available since the 1930’s.  Perhaps, tocotrienols are only recently available because they are more reactive, they are harder to extract and stabilize.  They are a much more powerful antioxidant then even tocopherols and are naturally occurring in plants

Benefits of Tocotrienols

The most common cholesterol lowering medications are Mevacor, Pravachol, Zocor and Lescol.  These “statin” drugs work on the enzyme, HMG CoA-reductase.  These medications work by blocking the receptor site that HMG CoA-reductase would normally attach itself to.  This lowers the total cholesterol, but the enzyme cannot attach to the receptor site and the body gets too much HMG CoA-reductase as a result.  Because the receptor site is blocked the HMG CoA-reductase goes up as much as 200% to try to overcome the blockage.  This excess enzyme is the possible reason for the “statin” side effects, which include cancer.

Tocotrienols encourage a natural breakdown of HMG CoA-reductase and thereby reduce total cholesterol without side effects.  In addition, tocotrienols lower LDL, the “bad” cholesterol, by approximately 20%.  Laboratory studies on cancer show that the presence of tocotrienols reduce or stop the growth of cancer.

Sesame Seed Oil Maximizes Vitamin E Anti-thrombin Activity

Vitamin E has been shown to prevent platelet aggregation or clots occurring inside the blood vessel.  Sesame seed oil is rich in T-factors, sometimes called vitamin T, which also reduce platelet aggregation, further reducing the risk of thrombi.  Natural enzymes in raw sesame oil enhance the body's ability to absorb the fat soluble vitamin. Sesame is a highly digestible oil which, like other vegetable oils, dissolves vitamin E and releases it readily in the body.  E-400 Toco 400 contains a full 200 mg. of certified organic, unrefined sesame seed oil. It contains no soybean oil.

Four Major Functions of Vitamin E

According to Dr. Evan Shute, one of the worlds foremost authorities on vitamin E, four major functions, all extensively confirmed in animal experimentation and human clinical work, make it the most valuable ally yet found in the treatment of heart disease.

1.  Natural anti-thrombin - circulates in the blood and prevents platelet aggregation or clots occurring inside the vessel, but does not interfere with the normal clotting process in wounds or with normal healing. In fact, it actually accelerates healing of burns and wounds. This is important not only in the treatment of heart disease, but in treating phlebitis and varicose veins caused by blood clots and venous obstructions. Tocotrienols also inhibit platelets by blocking thromboxane A2, which is exactly how aspirin works to cut the risk of heart attacks.  Of course, Vitamin E does not have the possible side effects of aspirin.  Sesame oil further reduces the risk of thrombi.

2.  Oxygen conservation -  decreases the oxygen requirement of muscle by as much as 43%. This makes the stream of blood which passes through narrowed arteries in many heart patients, adequate to prevent anoxia (lack of oxygen) which triggers anginal pain.  Athletic performance and  endurance are also enhanced due to oxygen conservation.

3.  Collateral circulation - Vitamin E dilates blood vessels and opens up new pathways in the damaged circulatory system to bypass blocks produced by clots and hardened arteries. Intermittent claudication, a severe pain in calf muscles which results from inadequate blood supply, is relieved due to vitamin E's ability to conserve oxygen and to increase blood supply by dilating blood vessels.

4.  Scarring - prevents production of excessive scar tissue and, in some instances, can melt away unwanted scar tissue. This function has been seen in many areas of the body both internally and externally. Scarring from, burns, wounds and acne may be reduced or eliminated by simultaneous oral supplementation and external application of vitamin E.

These and other properties make vitamin E useful in treatment and prevention of many conditions throughout the body. Vitamin E has been shown to significantly reduce the need for insulin in diabetic patients due to it’s role in synthesis of coenzyme Q, a factor in the respiratory chain that releases energy from carbohydrates and fats.

Protects against Damage from
Free Radicals and Environmental Pollutants  at the Cellular Level

Vitamin E protects cell membranes from the destructive effects of oxygen free radicals and environmental pollutants. Jeffrey Bland, Ph.D., explains “Vitamin E has a great affinity for cell membranes because these membranes contain large amounts of unsaturated fatty acids and other fats, and vitamin E is a fat soluble vitamin.”

For this reason the effects of vitamin E are seen throughout the body.

• Premature aging may result from by collagen cross-linkng caused by the destructive effects of free radicals and environmental pollutants. As an antioxidant, vitamin E protects against these and may slow down such symptoms as wrinkling of the skin.
• Male fertility has been improved with vitamin E supplementation. Although potency is not affected, fertility is improved due to its protective effect on sperm cell membranes.
• Sickle cell anemia patients have seen a reduction in blood levels of irreversibly sickled cells (IRC) with vitamin E supplementation. Vitamin E's action as an antioxidant may alter the stability of the red blood cell membrane, making it less vulnerable to bending and distortion.
• Cancer prevention and treatment are enhanced by vitamin E because of its protective effect on cell membranes. It has also been shown to potentiate the antioxidant effect of selenium and to reduce toxic side effects of radiation and drugs used in cancer treatment.

Vitamin E's antioxidant action prevents the breakdown of fatty acids and vitamin A. When these nutrients are increased, or when the diet is high in polyunsaturated fats, vitamin E intake should be increased proportionately.

Special Needs of Women

Vitamin E has a positive effect on the female reproductive system and has proven effective in alleviating a number of conditions.

• Habitual miscarriage may be avoided. Vitamin E strengthens the villi which attach the placenta to the uterine wall.
• Premature births frequently result from inadequate vitamin E intake during pregnancy, leaving the infant more susceptible to anemia.
• Fibrocystic disease of the breast has responded well to vitamin E supplementation in clinical tests by gynecologist Robert London, M.D.
• Breast cancer patients tested for plasma levels of vitamins A, E and beta carotene showed lower levels of beta carotene and significantly lower levels of vitamin E than controls.
• PMS symptoms have been alleviated in some women by vitamin E supplementation.
• Menopausal symptoms of headache and hot flashes have responded well to vitamin E.

WARNING: This information is provided for the health professionals only. This publication and the product contained herein have not been approved or evaluated by the Food and Drug Administration. This publication, and the product contained herein are not intended to diagnose, treat, cure or prevent any disease. The product relates to nutritional support only.

References

1.Shute, Evan, The Heart and Vitamin E, Shute Foundation of London, Ontario, Canada, 1963.

2.Shute, Wilfred E. and Taub, H.J.,  Vitamin E for Ailing and Healthy Hearts, Pyramid House, New York, 1969.

3.Pfeiffer, Carl, Mental and Elemental Nutrients, Keats Publishing, New Canaan, CT, 1975.

4.Wald, N.J., et. al., Vitamin A, Carotene, Vitamin E and Breast Cancer, British Journal of Cancer, 1984.

5.London, Robert, Vitamin E Helps Protect the Breasts, Prevention, April, 1977.

6.Garrison, R and Somer, E., The Nutrition Desk Reference, Keats Publishing, New Canaan, CT, 1985.

7.Nutrition Search, Inc. Nutrition Almanac, McGraw Hill, 1984.

8.Bland, Jeffrey, 1986 a Year in Nutritional Medicine, Keats Publishing, New Canaan, CT. 1987.

9.The Complete Book of Vitamins, Rodale, Emmaus, PA, 1984.

10.Gey, Fred, Puska, Pekka, Jordan, Paul and Moser, Ulrich, Inverse Correlation between Plasma Vitamin E and Mortality from Ischemic Heart Disease in Cross-Cultural Epidemiology, American Journal of Clinical Nutrition, Jan., 1991.

11.Nutrition & Healing, January 1998.

These statements have not been evaluated by the FDA. 
This product is not intended to prevent, treat, cure, mitigate or diagnose any disease.

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